KNINDEX

NMN

What are the criteria for choosing a good NMN product?

1

Clinically studied dose (≥250 mg/day)① Effective dose /30

The minimum dose with demonstrated efficacy is 250 mg/day (Yoshino 2021, Igarashi 2022); a dose-response trial found 600 mg the efficiency sweet spot. Products with tens of milligrams fall below any studied dose.

How to check — Check NMN per daily serving — not per bottle.

Evidence:Yoshino 2021, ScienceIgarashi 2022, npj AgingYi 2023, GeroScience

2

β-isomer, ≥99% purity② Purity & impurity testing /25

All human clinical trials to date used the β-isomer. The α-form has no evidence of biological activity.

How to check — Check the manufacturer's COA for HPLC purity results and the explicit 'β-Nicotinamide Mononucleotide' designation.

Evidence:Yi 2023, GeroScience

3

Third-party verified content② Purity & impurity testing /25

In an independent analysis of 15 global NMN products, 3 contained no detectable NMN and only 7 were within ±10% of label — making this the single most important criterion in this category.

How to check — Look for published lot-specific third-party assay reports. In-house testing alone is a weaker signal.

Evidence:Sandalova 2024, GeroScience

4

Stabilized form & moisture-proof packaging③ Manufacturing & safety certification /20

NMN degrades into nicotinamide with heat and moisture; degradation during distribution is a suspected cause of under-label content.

How to check — Check for a stabilized crystalline form, desiccant/moisture-proof packaging, and storage guidance.

Evidence:Sandalova 2024, GeroScience

5

cGMP manufacture + independent certification③ Manufacturing & safety certification /20

Adulteration with cheap nicotinamide has been reported in this category, making cGMP manufacture and independent certifications (NSF, Informed Choice) especially valuable.

How to check — Verify FDA-registered cGMP (21 CFR Part 111) manufacture and validate certification marks in the certifier's database.

Evidence:Sandalova 2024, GeroScience

6

Regulation-compliant supply chain (NDI)⑤ Information transparency /10

With NDI status reinstated in December 2025, a traceable lawful supply chain is verifiable. Opaque ingredient sourcing is a red flag.

How to check — Check whether the brand discloses its raw-material supplier (e.g., an NDI-notified source).

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