4Is the ingredient brand named? (Unnamed raw material = unverifiable.)
5What is the price per 100 mg once converted?
NMN is a direct NAD+ precursor; raising blood NAD+ at 250–1,000 mg/day is the most consistently reproduced human finding (2024 meta-analysis: 12 RCTs, n=513). Muscle insulin sensitivity improved in peri-menopausal women at 250 mg for 10 weeks (Yoshino 2021, Science), and no serious adverse events were reported up to 1,200 mg/day for 24 weeks. However, a 2025 meta-analysis in older adults found no significant gain in muscle mass or grip strength — NAD+ elevation is established, functional benefit is still under study. What matters when choosing: published β-purity ≥99%, an actual daily dose of ≥250 mg, and price per 100 mg.
01Effects & latest research
What does NMN do, and what does recent research say?
What is established
NMN is a direct NAD+ precursor, and raising blood NAD+ after oral intake is the most consistently reproduced result in human research (2024 meta-analysis: 12 RCTs, n=513, consistent NAD+ elevation at 250–1,000 mg/day). NAD+ participates in cellular energy metabolism and DNA repair, and declines with age.
What is new
In peri-menopausal overweight women, 250 mg/day for 10 weeks improved skeletal-muscle insulin sensitivity (Yoshino et al., Science, 2021). Studies in middle-aged and older adults report improvements in walking ability and sleep quality (250–600 mg, 2022–2023). No serious adverse events have been reported up to 1,200 mg/day for 24 weeks.
Limits — we stop here
A 2025 meta-analysis of muscle function in older adults found no significant improvement in muscle mass or grip strength. KNI states this plainly: NAD+ elevation is established; functional benefit remains under investigation. That honesty is what makes the grading credible.
The ranges below are those used in human studies, not a therapeutic prescription.
Segment
Range
Basis / note
Women (30s–40s)
250 mg
Dose shown effective in peri-menopausal women (Science 2021)
Men (30s–50s)
250–500 mg
Most metabolic and functional studies sit in this range
50+ / intensive
500–900 mg
High-dose study range; above 900 mg the added-benefit evidence weakens
Studied safety ceiling
1,200 mg / 24 weeks
No serious adverse events. Not a drug — consult a professional if you have a condition
Women (30s–40s)250 mg
Dose shown effective in peri-menopausal women (Science 2021)
Men (30s–50s)250–500 mg
Most metabolic and functional studies sit in this range
50+ / intensive500–900 mg
High-dose study range; above 900 mg the added-benefit evidence weakens
Studied safety ceiling1,200 mg / 24 weeks
No serious adverse events. Not a drug — consult a professional if you have a condition
03Quality standards & impurities
What quality criteria separate a good NMN product?
Standard
How to verify
Purity ≥99%
Published β-NMN purity plus third-party HPLC COA. Undisclosed purity is a decisive deduction.
Daily dose ≥250 mg
Convert to actual daily intake — ignore the number in the product name (e.g. "15000").
Manufacturing & safety
FDA-registered cGMP facility, US Self-Affirmed GRAS, GLP-lab toxicology data.
Stabilised form & moisture-proof packaging
NMN degrades into nicotinamide with heat and moisture, and degradation in distribution is a suspected cause of under-label content. Check for a stabilised crystalline form, single-dose or moisture-proof packaging, and storage guidance.
Authenticity risk
US market surveys report under-dosing and adulteration among unbranded NMN. Treat ultra-cheap imports without a COA with caution.
Purity ≥99%
Published β-NMN purity plus third-party HPLC COA. Undisclosed purity is a decisive deduction.
Daily dose ≥250 mg
Convert to actual daily intake — ignore the number in the product name (e.g. "15000").
Manufacturing & safety
FDA-registered cGMP facility, US Self-Affirmed GRAS, GLP-lab toxicology data.
Stabilised form & moisture-proof packaging
NMN degrades into nicotinamide with heat and moisture, and degradation in distribution is a suspected cause of under-label content. Check for a stabilised crystalline form, single-dose or moisture-proof packaging, and storage guidance.
Authenticity risk
US market surveys report under-dosing and adulteration among unbranded NMN. Treat ultra-cheap imports without a COA with caution.
The raw material decides quality more than the finished brand. Note the difference between a product that names its source and one that does not.
ROKIT NMN
Rokit Healthcare (KR/US entities)
—US Self-Affirmed GRAS, reviewed by an AIBMR-convened toxicology expert panel
—GLP-lab 90-day repeat-dose and genotoxicity studies completed
—HPLC-based impurity control (NR, NAM)
—Batch-level stability data
Uthever®
EffePharm (CN, global supply)
—Purity ≥99.5%
—Self-Affirmed GRAS
—66-subject double-blind human trial (2022) reporting 38% NAD+/NADH rise over 2 months
—EU Novel Food process under way; cGMP production
05Graded product matching
Which NMN products earn which grade?
Conflict-of-interest disclosure: KNI and EGA share ownership and management. EGA products are included in our NMN comparisons. We apply the same published criteria to all products; please review the evidence behind EGA's score.
Grade
Product
Total
Cost per active unit/100mg
Daily costWomen 250mg / Men 375mg
Days of supplyWomen / Men
S
EGA NMN Daily RegeneratorShared ownership with KNI
250 mg/day, published 99.9% purity, named ROKIT NMN® ingredient brand with public third-party COA verified (Aug 2026), plus 60 mg Dermial® (hyaluronic acid, collagen, elastin complex) — made in the US, sold via cross-border purchase; a stick powder taken without water
Retailer link pending
92/100
876원Based on the 3-box set, 197,000 KRW for 90 sticks
2,189원 / 3,283원
90 / 60d1 / 1.5 sticks/day
S
Rokit America NMN + Pterostilbene
250 mg/day, 99.9% purity, combined with pterostilbene (polyphenol stack) — capsule format aimed at research-style stacking
Retailer link pending
90/100
680원
1,700원 / 2,550원
30 / 20d1 / 1.5 capsules/day
A
ProHealth NMN Pro (Uthever®)
250–500 mg/day, third-party HPLC testing, sustained-release tablet. An S candidate once Self-GRAS and GLP documentation is verified
Retailer link pending
78/100
Not calculable
Not calculable
—
B
Double Wood NMN
250 mg/day, purity 97%+ (below 99%), COA published — budget tier
No COA, undisclosed purity and sourcing — a category where US market surveys report under-dosing and adulteration
10/100
Not calculable
Not calculable
—
S
92/100
EGA NMN Daily Regenerator
Shared ownership with KNI
250 mg/day, published 99.9% purity, named ROKIT NMN® ingredient brand with public third-party COA verified (Aug 2026), plus 60 mg Dermial® (hyaluronic acid, collagen, elastin complex) — made in the US, sold via cross-border purchase; a stick powder taken without water
Cost per active unit
876원/100mg
Price basis
Based on the 3-box set, 197,000 KRW for 90 sticks
Daily cost · Women 250mg
2,189원
Daily cost · Men 375mg
3,283원
Days of supply · Women / Men
90 / 60d
Servings per day
1 / 1.5 sticks
Axis scores
Effective dose
30/30
Purity & impurity testing
24/25
Manufacturing & safety certification
17/20
Raw-material grade
13/15
Information transparency
8/10
Retailer link pending
S
90/100
Rokit America NMN + Pterostilbene
250 mg/day, 99.9% purity, combined with pterostilbene (polyphenol stack) — capsule format aimed at research-style stacking
Cost per active unit
680원/100mg
Daily cost · Women 250mg
1,700원
Daily cost · Men 375mg
2,550원
Days of supply · Women / Men
30 / 20d
Servings per day
1 / 1.5 capsules
Axis scores
Effective dose
30/30
Purity & impurity testing
24/25
Manufacturing & safety certification
17/20
Raw-material grade
13/15
Information transparency
6/10
Retailer link pending
A
78/100
ProHealth NMN Pro (Uthever®)
250–500 mg/day, third-party HPLC testing, sustained-release tablet. An S candidate once Self-GRAS and GLP documentation is verified
Cost per active unit
Not calculable
Daily cost · Women 250mg
—
Daily cost · Men 375mg
—
Days of supply · Women / Men
—
Axis scores
Effective dose
26/30
Purity & impurity testing
20/25
Manufacturing & safety certification
12/20
Raw-material grade
13/15
Information transparency
7/10
Retailer link pending
B
61/100
Double Wood NMN
250 mg/day, purity 97%+ (below 99%), COA published — budget tier
Cost per active unit
Not calculable
Daily cost · Women 250mg
—
Daily cost · Men 375mg
—
Days of supply · Women / Men
—
Axis scores
Effective dose
26/30
Purity & impurity testing
14/25
Manufacturing & safety certification
10/20
Raw-material grade
4/15
Information transparency
7/10
Retailer link pending
C
10/100
Unbranded import / marketplace NMN
No COA, undisclosed purity and sourcing — a category where US market surveys report under-dosing and adulteration
Cost per active unit
Not calculable
Daily cost · Women 250mg
—
Daily cost · Men 375mg
—
Days of supply · Women / Men
—
Axis scores
Effective dose
8/30
Purity & impurity testing
0/25
Manufacturing & safety certification
0/20
Raw-material grade
0/15
Information transparency
2/10
See axis-level scores (5 axes, 100 points)
Product
① Effective dose/30
② Purity & impurity testing/25
③ Manufacturing & safety certification/20
④ Raw-material grade/15
⑤ Information transparency/10
EGA NMN Daily Regenerator
30
24
17
13
8
Rokit America NMN + Pterostilbene
30
24
17
13
6
ProHealth NMN Pro (Uthever®)
26
20
12
13
7
Double Wood NMN
26
14
10
4
7
Unbranded import / marketplace NMN
8
0
0
0
2
EGA NMN Daily Regenerator
① Effective dose
30/30
② Purity & impurity testing
24/25
③ Manufacturing & safety certification
17/20
④ Raw-material grade
13/15
⑤ Information transparency
8/10
Rokit America NMN + Pterostilbene
① Effective dose
30/30
② Purity & impurity testing
24/25
③ Manufacturing & safety certification
17/20
④ Raw-material grade
13/15
⑤ Information transparency
6/10
ProHealth NMN Pro (Uthever®)
① Effective dose
26/30
② Purity & impurity testing
20/25
③ Manufacturing & safety certification
12/20
④ Raw-material grade
13/15
⑤ Information transparency
7/10
Double Wood NMN
① Effective dose
26/30
② Purity & impurity testing
14/25
③ Manufacturing & safety certification
10/20
④ Raw-material grade
4/15
⑤ Information transparency
7/10
Unbranded import / marketplace NMN
① Effective dose
8/30
② Purity & impurity testing
0/25
③ Manufacturing & safety certification
0/20
④ Raw-material grade
0/15
⑤ Information transparency
2/10
How these are calculated
Cost per active unit = price ÷ total active content · Daily cost = cost per unit × daily dose · Days of supply = total active content ÷ daily dose
Unit costs are converted from the purchase option listed at the official retailer. Where the basis is not a single unit, that option is stated beneath the figure — costs on different bases are not directly comparable.
Days of supply is not how long an effect lasts — it is how many days one pack covers at the daily dose used here. Nor is it the number of sticks or tablets in a pack: when the daily dose exceeds one serving, a 30-stick pack lasts fewer than 30 days.
Daily dose used — Women 250mg · Men 375mg. 250 mg for women is the dose shown effective in peri-menopausal women (Science 2021); 375 mg for men is the midpoint of the 250–500 mg range used in metabolic and functional studies, chosen by KNI as the comparison basis.
All named products in this table are made in the US and sold via cross-border purchase. Named listings are limited to overseas brands and to top-tier (S/A) domestic products whose evidence — ingredient brand, certifications and test reports — is publicly verifiable. All other domestic products appear as a category. Third-party product links earn no affiliate commission. KNI and EGA share ownership and management; purchases do not change the published scoring criteria. Based on official retailer listings and published test reports · Data as of 2026-08
So which one should you choose?
To summarise the standard — 250 mg a day, purity of 99% or above with test results, certification, named sourcing, and price per 100 mg. Among the named products, two reach S grade against it.
If you want a no-water stick with skin support —
SEGA NMN Daily Regenerator876원/100mg
A 250 mg stick powder (the dose studied in women) taken without water, with hyaluronic acid, collagen and elastin alongside. Daily cost runs higher than single-ingredient options.
If you want research-style stacking —
SRokit America NMN + Pterostilbene680원/100mg
A polyphenol stack with pterostilbene and a deep raw-material verification record (Self-GRAS, GLP). It is a capsule, so it needs water.
Whichever you choose, it should now be clear what to look for on the label.
Conflict-of-interest disclosure: KNI and EGA share ownership and management. EGA products are included in our NMN comparisons. We apply the same published criteria to all products; please review the evidence behind EGA's score.
No — there is no evidence for that claim. Human studies show increased blood NAD+ and improvements in specific functional measures (muscle insulin sensitivity, walking function in older adults). Lifespan extension is animal-only data, and a 2024 meta-analysis found limited effects on glucose and lipids.
The 2022 FDA action was a legal-process issue (drug preclusion), not a safety finding, and the FDA formally reversed it in September 2025 — NMN is now a lawful supplement ingredient in the US. Trials reported no serious adverse events up to 2000 mg/day short-term. Note that Korea's MFDS has not approved it as a functional-food ingredient.
NMN vs NR vs nicotinamide — what's the difference?
All three are NAD+ precursors but distinct compounds; NMN sits one step later than NR in the NAD+ synthesis pathway. Unlike niacin, NMN has no reported flushing. Adulteration cases substituting cheap nicotinamide for NMN have been reported — check the COA.
There is no conclusive answer. One RCT in adults 65+ found afternoon intake more beneficial for daytime drowsiness and lower-limb function, but that single study is not definitive. Total dose and consistency matter more.
Pregnant or nursing women, children, and people undergoing cancer treatment should consult a clinician first — long-term safety data are lacking, and there is a theoretical (not clinically established) concern about NAD+ and tumor metabolism. Korean residents should note NMN is not an approved functional food in Korea.
