4Is the ingredient brand named? (Unnamed raw material = unverifiable.)
5What is the price per 100 mg once converted?
NMN is a direct NAD+ precursor; raising blood NAD+ at 250–1,000 mg/day is the most consistently reproduced human finding (2024 meta-analysis: 12 RCTs, n=513). Muscle insulin sensitivity improved in peri-menopausal women at 250 mg for 10 weeks (Yoshino 2021, Science), and no serious adverse events were reported up to 1,200 mg/day for 24 weeks. However, a 2025 meta-analysis in older adults found no significant gain in muscle mass or grip strength — NAD+ elevation is established, functional benefit is still under study. What matters when choosing: published β-purity ≥99%, an actual daily dose of ≥250 mg, and price per 100 mg.
01Effects & latest research
What does NMN do, and what does recent research say?
What is established
NMN is a direct NAD+ precursor, and raising blood NAD+ after oral intake is the most consistently reproduced result in human research (2024 meta-analysis: 12 RCTs, n=513, consistent NAD+ elevation at 250–1,000 mg/day). NAD+ participates in cellular energy metabolism and DNA repair, and declines with age.
What is new
In peri-menopausal overweight women, 250 mg/day for 10 weeks improved skeletal-muscle insulin sensitivity (Yoshino et al., Science, 2021). Studies in middle-aged and older adults report improvements in walking ability and sleep quality (250–600 mg, 2022–2023). No serious adverse events have been reported up to 1,200 mg/day for 24 weeks.
Limits — we stop here
A 2025 meta-analysis of muscle function in older adults found no significant improvement in muscle mass or grip strength. KNI states this plainly: NAD+ elevation is established; functional benefit remains under investigation. That honesty is what makes the grading credible.
The ranges below are those used in human studies, not a therapeutic prescription.
Segment
Range
Basis / note
Women (30s–40s)
250 mg
Dose shown effective in peri-menopausal women (Science 2021)
Men (30s–50s)
250–500 mg
Most metabolic and functional studies sit in this range
50+ / intensive
500–900 mg
High-dose study range; above 900 mg the added-benefit evidence weakens
Studied safety ceiling
1,200 mg / 24 weeks
No serious adverse events. Not a drug — consult a professional if you have a condition
Women (30s–40s)250 mg
Dose shown effective in peri-menopausal women (Science 2021)
Men (30s–50s)250–500 mg
Most metabolic and functional studies sit in this range
50+ / intensive500–900 mg
High-dose study range; above 900 mg the added-benefit evidence weakens
Studied safety ceiling1,200 mg / 24 weeks
No serious adverse events. Not a drug — consult a professional if you have a condition
03Quality standards & impurities
What quality criteria separate a good NMN product?
Standard
How to verify
Purity ≥99%
Published β-NMN purity plus third-party HPLC COA. Undisclosed purity is a decisive deduction.
Daily dose ≥250 mg
Convert to actual daily intake — ignore the number in the product name (e.g. "15000").
Manufacturing & safety
FDA-registered cGMP facility, US Self-Affirmed GRAS, GLP-lab toxicology data.
Stabilised form & moisture-proof packaging
NMN degrades into nicotinamide with heat and moisture, and degradation in distribution is a suspected cause of under-label content. Check for a stabilised crystalline form, single-dose or moisture-proof packaging, and storage guidance.
Authenticity risk
US market surveys report under-dosing and adulteration among unbranded NMN. Treat ultra-cheap imports without a COA with caution.
Purity ≥99%
Published β-NMN purity plus third-party HPLC COA. Undisclosed purity is a decisive deduction.
Daily dose ≥250 mg
Convert to actual daily intake — ignore the number in the product name (e.g. "15000").
Manufacturing & safety
FDA-registered cGMP facility, US Self-Affirmed GRAS, GLP-lab toxicology data.
Stabilised form & moisture-proof packaging
NMN degrades into nicotinamide with heat and moisture, and degradation in distribution is a suspected cause of under-label content. Check for a stabilised crystalline form, single-dose or moisture-proof packaging, and storage guidance.
Authenticity risk
US market surveys report under-dosing and adulteration among unbranded NMN. Treat ultra-cheap imports without a COA with caution.
The raw material decides quality more than the finished brand. Note the difference between a product that names its source and one that does not.
ROKIT NMN
Rokit Healthcare (KR/US)
—US Self-Affirmed GRAS, reviewed by an AIBMR-convened toxicology expert panel
—GLP-lab 90-day repeat-dose and genotoxicity studies completed
—HPLC-based impurity control (NR, NAM)
—Batch-level stability data
Uthever®
EffePharm (CN, global supply)
—Purity ≥99.5%
—Self-Affirmed GRAS
—66-subject double-blind human trial (2022) reporting 38% NAD+/NADH rise over 2 months
—EU Novel Food process under way; cGMP production
05Graded product matching
Which NMN products earn which grade?
Independence: This site is operated by KNI. Every product is scored against the same public criteria, and advertising or affiliate arrangements play no part in grading.
Grade
Product
Total
Cost per active unit/100mg
Daily costWomen / Men
Days of supply
S
Rokit America NMN + Pterostilbene (US)
250 mg/day, 99.9% purity, combined with pterostilbene (polyphenol stack) — capsule format aimed at research-style stacking
Retailer link pending
90/100
680원
1,700원 / 2,550원
30 / 20d
S
Domestic NMN stick complexCategory (not named)
250 mg/day, published 99.9% purity, with skin-related ingredients (hyaluronic acid, collagen, elastin) — a stick powder taken without water
85/100
Not calculable
Not calculable
—
A
ProHealth NMN Pro (US, Uthever®)
250–500 mg/day, third-party HPLC testing, sustained-release tablet. An S candidate once Self-GRAS and GLP documentation is verified
Retailer link pending
78/100
Not calculable
Not calculable
—
B
Double Wood NMN (US)
250 mg/day, purity 97%+ (below 99%), COA published — budget tier
No COA, undisclosed purity and sourcing — a category where US market surveys report under-dosing and adulteration
10/100
Not calculable
Not calculable
—
S
90/100
Rokit America NMN + Pterostilbene (US)
250 mg/day, 99.9% purity, combined with pterostilbene (polyphenol stack) — capsule format aimed at research-style stacking
Cost per active unit
680원/100mg
Daily cost · Women
1,700원
Daily cost · Men
2,550원
Days of supply
30 / 20d
Axis scores
Effective dose
30/30
Purity & impurity testing
24/25
Manufacturing & safety certification
17/20
Raw-material grade
13/15
Information transparency
6/10
Retailer link pending
S
85/100
Domestic NMN stick complex
250 mg/day, published 99.9% purity, with skin-related ingredients (hyaluronic acid, collagen, elastin) — a stick powder taken without water
Cost per active unit
Not calculable
Daily cost · Women
—
Daily cost · Men
—
Days of supply
—
Axis scores
Effective dose
30/30
Purity & impurity testing
22/25
Manufacturing & safety certification
15/20
Raw-material grade
10/15
Information transparency
8/10
A
78/100
ProHealth NMN Pro (US, Uthever®)
250–500 mg/day, third-party HPLC testing, sustained-release tablet. An S candidate once Self-GRAS and GLP documentation is verified
Cost per active unit
Not calculable
Daily cost · Women
—
Daily cost · Men
—
Days of supply
—
Axis scores
Effective dose
26/30
Purity & impurity testing
20/25
Manufacturing & safety certification
12/20
Raw-material grade
13/15
Information transparency
7/10
Retailer link pending
B
61/100
Double Wood NMN (US)
250 mg/day, purity 97%+ (below 99%), COA published — budget tier
Cost per active unit
Not calculable
Daily cost · Women
—
Daily cost · Men
—
Days of supply
—
Axis scores
Effective dose
26/30
Purity & impurity testing
14/25
Manufacturing & safety certification
10/20
Raw-material grade
4/15
Information transparency
7/10
Retailer link pending
C
10/100
Unbranded import / marketplace NMN
No COA, undisclosed purity and sourcing — a category where US market surveys report under-dosing and adulteration
Cost per active unit
Not calculable
Daily cost · Women
—
Daily cost · Men
—
Days of supply
—
Axis scores
Effective dose
8/30
Purity & impurity testing
0/25
Manufacturing & safety certification
0/20
Raw-material grade
0/15
Information transparency
2/10
See axis-level scores (5 axes, 100 points)
Product
① Effective dose/30
② Purity & impurity testing/25
③ Manufacturing & safety certification/20
④ Raw-material grade/15
⑤ Information transparency/10
Rokit America NMN + Pterostilbene (US)
30
24
17
13
6
Domestic NMN stick complex
30
22
15
10
8
ProHealth NMN Pro (US, Uthever®)
26
20
12
13
7
Double Wood NMN (US)
26
14
10
4
7
Unbranded import / marketplace NMN
8
0
0
0
2
Rokit America NMN + Pterostilbene (US)
① Effective dose
30/30
② Purity & impurity testing
24/25
③ Manufacturing & safety certification
17/20
④ Raw-material grade
13/15
⑤ Information transparency
6/10
Domestic NMN stick complex
① Effective dose
30/30
② Purity & impurity testing
22/25
③ Manufacturing & safety certification
15/20
④ Raw-material grade
10/15
⑤ Information transparency
8/10
ProHealth NMN Pro (US, Uthever®)
① Effective dose
26/30
② Purity & impurity testing
20/25
③ Manufacturing & safety certification
12/20
④ Raw-material grade
13/15
⑤ Information transparency
7/10
Double Wood NMN (US)
① Effective dose
26/30
② Purity & impurity testing
14/25
③ Manufacturing & safety certification
10/20
④ Raw-material grade
4/15
⑤ Information transparency
7/10
Unbranded import / marketplace NMN
① Effective dose
8/30
② Purity & impurity testing
0/25
③ Manufacturing & safety certification
0/20
④ Raw-material grade
0/15
⑤ Information transparency
2/10
Third-party comparisons are limited to overseas brands. Among domestically distributed products, only our own is included. Product links carry no affiliate arrangement. A purchase through a link does not affect any grade or its position. Based on official retailer listings and published test reports · Data as of 2026-08
So which one should you choose?
To summarise the standard — 250 mg a day, purity of 99% or above with test results, certification, named sourcing, and price per 100 mg. Among the named products, one reaches S grade against it.
If you want research-style stacking —
로SRokit America NMN + Pterostilbene (US)680원/100mg
A polyphenol stack with pterostilbene and a deep raw-material verification record (Self-GRAS, GLP). It is a capsule, so it needs water.
Retailer link pending
Whichever you choose, it should now be clear what to look for on the label.
Independence: This site is operated by KNI. Every product is scored against the same public criteria, and advertising or affiliate arrangements play no part in grading.
No — there is no evidence for that claim. Human studies show increased blood NAD+ and improvements in specific functional measures (muscle insulin sensitivity, walking function in older adults). Lifespan extension is animal-only data, and a 2024 meta-analysis found limited effects on glucose and lipids.
The 2022 FDA action was a legal-process issue (drug preclusion), not a safety finding, and the FDA formally reversed it in September 2025 — NMN is now a lawful supplement ingredient in the US. Trials reported no serious adverse events up to 2000 mg/day short-term. Note that Korea's MFDS has not approved it as a functional-food ingredient.
NMN vs NR vs nicotinamide — what's the difference?
All three are NAD+ precursors but distinct compounds; NMN sits one step later than NR in the NAD+ synthesis pathway. Unlike niacin, NMN has no reported flushing. Adulteration cases substituting cheap nicotinamide for NMN have been reported — check the COA.
There is no conclusive answer. One RCT in adults 65+ found afternoon intake more beneficial for daytime drowsiness and lower-limb function, but that single study is not definitive. Total dose and consistency matter more.
Pregnant or nursing women, children, and people undergoing cancer treatment should consult a clinician first — long-term safety data are lacking, and there is a theoretical (not clinically established) concern about NAD+ and tumor metabolism. Korean residents should note NMN is not an approved functional food in Korea.
