Scored on the same 100-point, five-axis rubric. Named listings are limited to overseas brands and top-tier domestic products with publicly verifiable evidence; unverifiable low-quality items appear as a category rather than by name.
Published
2026-08-20
·
Last reviewed
2026-08-20
·
Data as of
2026-08 — Based on official retailer listings and published test reports
97% standardised with lot-level testing in an NSF-certified facility; 500 mg capsules make 1,000–1,500 mg/day easy to reach (~$0.33 per 500 mg)
Cost per active unit
Not calculable
Daily cost · Women 1g
—
Daily cost · Men 1g
—
Days of supply · Women / Men
—
Axis scores
Effective dose
30/30
Purity & impurity testing
23/25
Manufacturing & safety certification
18/20
Raw-material grade
8/15
Information transparency
9/10
Retailer link pending
A
73/100
Double Wood Berberine
Third-party testing and GMP, but weak standardisation labelling (~$0.33 per 500 mg)
Cost per active unit
Not calculable
Daily cost · Women 1g
—
Daily cost · Men 1g
—
Days of supply · Women / Men
—
Axis scores
Effective dose
28/30
Purity & impurity testing
18/25
Manufacturing & safety certification
14/20
Raw-material grade
5/15
Information transparency
8/10
Retailer link pending
B
56/100
BulkSupplements Berberine Powder
Ultra-low-cost powder with limited standardisation and lot-testing disclosure (~$0.09–0.20 per 500 mg)
Cost per active unit
Not calculable
Daily cost · Women 1g
—
Daily cost · Men 1g
—
Days of supply · Women / Men
—
Axis scores
Effective dose
26/30
Purity & impurity testing
12/25
Manufacturing & safety certification
10/20
Raw-material grade
0/15
Information transparency
8/10
Retailer link pending
C
11/100
"Contains Coptis extract" diet blends
Actual berberine content undisclosed — cost not calculable
Cost per active unit
Not calculable
Daily cost · Women 1g
—
Daily cost · Men 1g
—
Days of supply · Women / Men
—
Axis scores
Effective dose
5/30
Purity & impurity testing
0/25
Manufacturing & safety certification
4/20
Raw-material grade
0/15
Information transparency
2/10
See axis-level scores (5 axes, 100 points)
Product
① Effective dose/30
② Purity & impurity testing/25
③ Manufacturing & safety certification/20
④ Raw-material grade/15
⑤ Information transparency/10
Thorne Berberine (Berbevis®)
28
22
19
15
9
Toniiq Berberine 97%
30
23
18
8
9
Double Wood Berberine
28
18
14
5
8
BulkSupplements Berberine Powder
26
12
10
0
8
"Contains Coptis extract" diet blends
5
0
4
0
2
Thorne Berberine (Berbevis®)
① Effective dose
28/30
② Purity & impurity testing
22/25
③ Manufacturing & safety certification
19/20
④ Raw-material grade
15/15
⑤ Information transparency
9/10
Toniiq Berberine 97%
① Effective dose
30/30
② Purity & impurity testing
23/25
③ Manufacturing & safety certification
18/20
④ Raw-material grade
8/15
⑤ Information transparency
9/10
Double Wood Berberine
① Effective dose
28/30
② Purity & impurity testing
18/25
③ Manufacturing & safety certification
14/20
④ Raw-material grade
5/15
⑤ Information transparency
8/10
BulkSupplements Berberine Powder
① Effective dose
26/30
② Purity & impurity testing
12/25
③ Manufacturing & safety certification
10/20
④ Raw-material grade
0/15
⑤ Information transparency
8/10
"Contains Coptis extract" diet blends
① Effective dose
5/30
② Purity & impurity testing
0/25
③ Manufacturing & safety certification
4/20
④ Raw-material grade
0/15
⑤ Information transparency
2/10
How these are calculated
Cost per active unit = price ÷ total active content · Daily cost = cost per unit × daily dose · Days of supply = total active content ÷ daily dose
Unit costs are converted from the purchase option listed at the official retailer. Where the basis is not a single unit, that option is stated beneath the figure — costs on different bases are not directly comparable.
Days of supply is not how long an effect lasts — it is how many days one pack covers at the daily dose used here. Nor is it the number of sticks or tablets in a pack: when the daily dose exceeds one serving, a 30-stick pack lasts fewer than 30 days.
Daily dose used — Women 1g · Men 1g. 1,000 mg for both = a representative figure inside the 900–1,500 mg divided-dose range used in glycemic and metabolic studies. There is no evidence for a sex-based difference, so the same figure is used.
All named products in this table are made in the US and sold via cross-border purchase. Named listings are limited to overseas brands and to top-tier (S/A) domestic products whose evidence — ingredient brand, certifications and test reports — is publicly verifiable. All other domestic products appear as a category. Third-party product links earn no affiliate commission. KNI and EGA share ownership and management; purchases do not change the published scoring criteria. Based on official retailer listings and published test reports · Data as of 2026-08
So which one should you choose?
To summarise — actual berberine HCl content rather than Coptis extract, standardisation to 97%+ with lot testing, a cGMP/NSF facility, and absorption technology.
If you want to follow the study protocol as written —
SToniiq Berberine 97%
It publishes 97% standardisation and lot-level test results in 500 mg capsules, which reproduces the study protocol — 500 mg before meals — directly. It requires two to three doses a day.
If you want the low bioavailability engineered around —
SThorne Berberine (Berbevis®)
Berbevis® phytosome is a patented raw material with human absorption data — the direct answer to berberine's core weakness. Certification is the highest here, but it sits in a premium tier and its price is unconfirmed, so we could not calculate a per-serving cost.
Berberine is not "nature's Ozempic" and does not replace medication. Do not take it during pregnancy or breastfeeding, and consult a physician or pharmacist if you take any medication, including glucose-lowering drugs.
Conflict-of-interest disclosure: KNI and EGA share ownership and management. EGA products are included in our NMN comparisons. We apply the same published criteria to all products; please review the evidence behind EGA's score.
+The right answer to berberine's low bioavailability
+Highest certification level here
Unverified or unmet
−Price pending confirmation — per-serving cost not calculable
−Premium price tier
S
Toniiq Berberine 97%
97% standardised with lot-level testing in an NSF-certified facility; 500 mg capsules make 1,000–1,500 mg/day easy to reach (~$0.33 per 500 mg)
88/100
Criteria met
+97% standardisation with published lot-level results
+Format matches the study protocol (500 mg before meals)
+NSF-certified facility
Unverified or unmet
−No absorption-engineered raw material (e.g. phytosome), capping the raw-material axis
−Requires 2–3 doses per day
A
Double Wood Berberine
Third-party testing and GMP, but weak standardisation labelling (~$0.33 per 500 mg)
73/100
Criteria met
+Publishes third-party test results
+Good value
Unverified or unmet
−Weak standardisation labelling makes lot-to-lot variation hard to assess
−No named ingredient brand
B
BulkSupplements Berberine Powder
Ultra-low-cost powder with limited standardisation and lot-testing disclosure (~$0.09–0.20 per 500 mg)
56/100
Criteria met
+Lowest per-serving cost
Unverified or unmet
−Limited standardisation and lot-testing disclosure
−Powder measuring reduces dosing accuracy
C
"Contains Coptis extract" diet blends
Actual berberine content undisclosed — cost not calculable
11/100
Criteria met
—
Unverified or unmet
−Actual berberine content undisclosed — you cannot tell whether studied doses are reached
−Often paired with "nature's Ozempic" marketing; treat with caution
What was this scored on?
① Effective dose 30
Does the actual daily intake reach the dose range used in human studies — not the number in the product name?
② Purity & impurity testing 25
Published purity figures plus third-party COA, with verifiable impurity and heavy-metal testing.
③ Manufacturing & safety certification 20
cGMP/FDA-registered facilities, ingredient-specific certifications (Self-GRAS, NSF), and toxicology data (GLP).
④ Raw-material grade 15
Named ingredient brand — whether a verified supplier such as Creapure®, Uthever® or Setria® is used.
⑤ Information transparency 10
Full ingredient and dose disclosure, convertible labelling, and claims free of exaggeration.
Conflict-of-interest disclosure: KNI and EGA share ownership and management. EGA products are included in our NMN comparisons. We apply the same published criteria to all products; please review the evidence behind EGA's score. KNI grades reflect our own published criteria and are not a government or accreditation-body certification.
